It was recently found out that the excessive nitrogen stress response associated ferroptosis indeed participated in Con A-induced AIH, which was a pivotal step that drives the execution of immune-mediated hepatic damage, and the precise mechanism of Caveolin-1 (Cav-1) on protecting hepatocytes in AIH was linked to against the reactive nitrogen species (RNS)- mediated ferroptosis 64. This evidence concerns the gene CAV1 and autoimmune hepatitis.