FLG and Alzheimer disease: Th2 cytokines have been proved to be overexpressed in the lesions of acute AD patients, especially IL-13 19.Consistent with earlier researches, our study revealed that IL-13 inhibited the mRNA and protein expression of FLG, LOR, and IVL in HaCaT cells, and supported the essential role of IL-13 in the immune dysfunction and abnormal barrier homoeostasis of AD.