TWIST1 and breast carcinoma: Recently, it was also shown that TWIST1 is phosphorylated by Akt, in turn, TWIST1 transcriptionally upregulates AKT2 gene in breast cancer cells, and this induction leads to invasion and migration of breast cancer cells (Cheng et al., 2007; Cheng et al., 2008; Xue et al., 2012).