As gene expression data indicates ANXA1 overexpression in brain malignancies39,40 and our immunohistochemistry for the Anxa1 N-terminal domain showed strong signals in brain tumours (Fig. 1c, Supplementary Fig. 3), the IF7C(RR)-SN38 conjugate may be clinically relevant to treatment of brain tumours in humans. This evidence concerns the gene ANXA1 and brain neoplasm.