By contrast, significant CD8+ cell infiltration (92.2 cells/HPF) was seen at injection sites of B16-Luc cells in C57BL/6 mice that had recovered from B16-Luc brain tumours following IF7C(RR)-SN38 treatment (Fig. 6b, right; Fig. 6c). The gene discussed is CD8A; the disease is brain neoplasm.