Authors noted that some probiotics lead to decrease in C-reactive protein levels in healthy individuals, metabolic disorders, inflammatory bowel disease, arthritis and critically ill condition; decrease in TNF-α levels in healthy individuals, fatty liver, inflammatory bowel disease and hepatic cirrhosis; increase in IL-6 in cirrhosis and renal failure; and increase in IL-10 in arthritis. Here, TNF is linked to arthritic joint disease.