Many of our findings are consistent with observations in humans, in whom AD-like cognitive decline and epileptiform activity can result not only from the inheritance of FAD-linked APP mutations, but also from overexpression of WT hAPP resulting from duplications of the APP gene [60, 130] and from trisomy 21 [131], in which an additional WT APP allele is expressed from the extra copy of chromosome 21. Here, APP is linked to Alzheimer disease.