TNF and inflammatory bowel disease: When IBD is in stable remission, short-term use (less than two weeks) ofnon-steroidal anti-inflammatory drugs (NSAIDs), including selectivecyclooxygenase (COX)-2 inhibitors, is an option, but there should be a lowthreshold to start anti-TNF agents in order to prevent complications ofongoing axial SpA, especially if anti-TNF agents previously had a positiveeffect on the intestinal disease activity.8,12,24,26