Genome‐wide exome sequencing studies revealed recurrent alterations involving EZH2 and several other genes that influence histone methylation, including those encoding the H3K4 methyltransferases, MLL2 and MLL3, and the H3K27me3 demethylases KDM6A and KDM6B in MBs [45, 46, 49, 83, 84, 85, 86]. This evidence concerns the gene KMT2C and Mobius syndrome.