The effect size observed in this reduced IVW model was not greatly attenuated (OR = 0.51 [95% CI: 0.32–0.83], P = 7.03 × 10−3, Supplementary Table 8), supporting that the relationship between insulin and anorexia was not unduly biased by horizontal pleiotropy through IV effects on BMI. Here, INS is linked to Anorexia.