CD163 and obesity due to melanocortin 4 receptor deficiency: Current research has shown that DHA has obvious blood glucose lowering and anti-inflammatory effects [61], short-term supplementation of fish oil rich in DHA could significantly reduce Mononuclear cells / macrophage activating factor soluble CD163, triglyceride levels, etc. in patients with T2DM and help to interfere with T2DM and obesity-related complications [62].