Patients harboring loss-of-function mutations in Wnt co-receptors LRP5 and LRP6 are more likely to suffer from impaired glucose homeostasis, coronary disease, and osteoporosis [29,30]; in contrast, gain-of-function mutations in LRP5 are associated with increased adiposity and osteosclerosis [31]. The gene discussed is LRP5; the disease is osteosclerosis.