LOX and cancer: Cancer cells have been shown to remodel their surrounding matrix microenvironments through multiple mechanisms: through secretion of metalloproteinases that degrade matrix proteins,[64] expression of lysyl oxidases that crosslink collagen fibers,[65] and synthesis of proteoglycans that can modulate the fibrillar topography.[66] We believe that our observed length scale of ≈40 μm may represent the spatial transition between the synthesis (proximal to the cancer cells) and degradative (distal) remodeling processes.