In order of entry into the model, MMSE score (for 1 point increase—HR 0.84; 95% CI 0.79–0.90), amnestic type of MCI (HR 2.35; 95% CI 1.39–3.98), and age (for 1 year increase—HR 1.05; 95% CI 1.01–1.10) were associated with the progression to overt dementia, independent of sex and education; further adjustment for hs.CRP, multiple lacunar lesions and GDS score did not modify the results (data not shown). Here, MAP3K14 is linked to dementia.