Upregulated expression of utrophin has been found in dystrophinopathies and other disorders of muscle, including congenital myopathies, inflammatory myopathies, diabetic neuropathies, amyotrophic lateral sclerosis, spinal muscular atrophies, and minimal change myopathies.29 Here, UTRN is linked to neuromuscular disease caused by qualitative or quantitative defects of dystrophin.