Acacetin inhibits the proliferative activity of human non‐small‐cell lung cancer A549 cell line by promoting p53 and Fas/FasL apoptotic system,35 decreases the TPA‐induced adhesion, invasion, and migration of A549 cancer cells by inactivating JNK signalling pathway and reducing binding activities of NF‐kappaB and AP‐1,25 and inhibits the invasion and migration of DU145 cells by suppressing p38 MAPK signal pathway.36 This evidence concerns the gene TP53 and cancer.