CXCL8 and neoplasm: Other SASP components, such as IL‐6, IL‐1, IL‐8, TNF, CXCL/CCL chemokines, matrix proteases, and growth factors (VEGF, GM‐CSF), promote a pro‐inflammatory environment that presumably aids in macrophage‐, T‐cell‐, or NK cell‐mediated clearance of senescent cells—an important tumor suppressor mechanism in the stromal microenvironment (Gluck & Ablasser, 2019).