However, even though it is not a prespecified hypothesis and this study was not powered for it, low incidence of developing facial acneiform rash is considered to be an evidence that preemptive therapy with oral minocycline and heparinoid moisturizer in NSCLC patients receiving EGFR-TKIs can reduce the incidence and severity of facial acneiform rash. Here, EGFR is linked to exanthem.