This FAEISS study (NCCH1512) was designed to confirm the superior efficacy of reactive topical corticosteroid strategies employing serially ranking-DOWN from very strong topical steroids (compared with strategies employing serially ranking-UP from weak topical steroids) for facial acneiform rash induced by EGFR inhibitors in metastatic NSCLC and CRC. The gene discussed is EGFR; the disease is colorectal carcinoma.