KMT2A and acute myeloid leukemia: In TARGET, the AML patients with certain cytogenetic abnormalities, such as t(9;11)(p22;q23), t(10;11)(p11.2;q23), del5q, trisomy 21, and MLL1 translocation, had significantly higher DEPTH scores than the AML patients without such abnormalities (p < 0.05) (Fig. 10e), confirming the positive correlation between DEPTH scores and chromosomal/genomic instability.