As expected, we observed significant inverse correlations of DEPTH scores with B cell, CD8+ T cell, HLA, IFN, and TIL scores in pan-cancer (FDR < 1.0 × 10−100, ρ ≤ −0.25), and in 23, 18, 17, 19, and 19 individual cancer types, respectively (FDRsp < 0.05) (Fig. 4a). The gene discussed is CD8A; the disease is cancer.