Some of these proteins were tumor suppressors, including Rb, FOXO3, and p27, and many proteins were kinases and involved in the regulation of cell proliferation, differentiation, and apoptosis, such as c-KIT, AKT, EGFR, MAPK1/3, PRKCA, SRC, ACVRL1, and JNK2. The gene discussed is FOXO3; the disease is neoplasm.