Moreover, DEPTH scores were inversely correlated with the ratios of immune-stimulatory signature (CD8+ T cells) to immune-inhibitory signature (CD4+ regulatory T cells) in pan-cancer (p = 5.14 × 10−181, ρ = −0.31) and in 12 individual cancer types (FDRsp < 0.05) (Fig. 4b). The gene discussed is CD4; the disease is cancer.