We found that TP53-mutated tumors exhibited remarkably higher DEPTH scores than TP53-wildtype tumors in pan-cancer (p = 2.21 × 10−13) and in multiple individual cancer types, including BLCA, BRCA, LIHC, LUAD, LUSC, PRAD, STAD, and UCEC (FDR < 0.05) (Fig. 2b). This evidence concerns the gene TP53 and cancer.