TOP2A and cancer: Likewise, we observed significant positive correlations of TOP2A and RACGAP1 expression levels with DEPTH scores in 13 and 15 cancer types, respectively (FDRsp < 0.05) (Fig. 3g), as well as in pan-cancer (TOP2A: p = 6.98 × 10−93, ρ = 0.21; RACGAP1: p = 4.14 × 10−157, ρ = 0.28).