Finally, the diagnostic accuracy of BACE1 was evaluated by ROC curves and the area under ROC curves (AUC) calculation (Fig. 2) using the best compromises between sensitivity and specificity for the diagnosis of LOAD, VAD and MIXED dementia, with a cut-off of BACE1 activity of 16.9, 18.0, and 17.00, respectively. This evidence concerns the gene BACE1 and dementia.