BACE1 and amyloidosis: Although it might be challenging to establish from post-mortem tissue whether a specific change is a late or early event or an epiphenomenon in disease pathogenesis24, Cole et al. showed that BACE1 elevation was correlated with amyloid pathology in mouse models both in the absence (model: Tg2576) and presence (5XFAD) of significant neuronal loss24,25.