Nuclear localization of Foxo is regulated by Alk-driven AKT/PI3K signaling in insulin-producing cells in the Drosophila brain23 and, similarly, oncogenic ALK variants affect FOXO3a localization in human anaplastic large-cell lymphoma (ALCL) and neuroblastoma cell culture models71,78. The gene discussed is INS; the disease is anaplastic large cell lymphoma.