LMNA and Hutchinson-Gilford progeria syndrome: Due to overt clinical similarities with MADA, our group searched for LMNA mutations in patients affected with Hutchinson–Gilford Progeria Syndrome (HGPS)10 and identified a recurrent de novo LMNA mutation affecting Lamin A splicing and causing the accumulation of a toxic prelamin A derivative called Progerin11,12.