Two major types of MAD are differentiated according to body fat distribution patterns and genetic origins: type A (MADA) characterized by partial lipodystrophy, caused by mutations of the Lamin A/C (LMNA) gene1 and type B (MADB) with generalized lipodystrophy, caused by mutations of the zinc metalloproteinase (ZMPSTE24) gene2. This evidence concerns the gene LMNA and generalized lipodystrophy.