This pathway links Nlrp1- and Casp1-mediated inflammation to Casp6-mediated neurodegeneration and AD pathologies including Aβ increased production, Tau cleavage, misfolded protein proteasomal clearance problems, cleavage of several cytoskeletal and synaptic proteins, and IL-1β production16,21–24. Here, NLRP1 is linked to Alzheimer disease.