This pathway links Nlrp1- and Casp1-mediated inflammation to Casp6-mediated neurodegeneration and AD pathologies including Aβ increased production, Tau cleavage, misfolded protein proteasomal clearance problems, cleavage of several cytoskeletal and synaptic proteins, and IL-1β production16,21–24. The gene discussed is CASP6; the disease is Alzheimer disease.