Notably, upon analysis of bulk RNA in the 32 colon cancer patient samples, we found that ciRS-7 was significantly positively correlated with FOS (r = 0.84, P < 0.0001), NR4A3 (r = 0.80, P < 0.0001) and PIK3CD (r = 0.40, P = 0.02). Here, PIK3CD is linked to malignant colon neoplasm.