In mice bearing CT26 or MC38 tumors, blocking anti-GARP:TGF-β1 mAbs did not induce tumor regression when administered alone, in line with observations in mice carrying a Treg-specific deletion of the Garp gene, which did not show reduced growth of MC38 or GL261 tumors by comparison to WT (Fig. 7 and Vermeersch et al.34). The gene discussed is DDX53; the disease is neoplasm.