None of the other examined markers from Panels A and B, including among others CX3CR1, IRF8, IRF7, CD11b, CD11c, CD86, CD45, TREM2, APOE, AXL, CD33 (Siglec-3), CD54 (ICAM1), CD56 (NCAM), GPR56, CD74, TGFβ, IFN-α, Galanin, CD95 (Fas), PD-L1, and Glut5, were differentially expressed between huMG/macrophages from MDD and control cases (data not shown). Here, IRF8 is linked to major depressive disorder.