Notably, the mix of ADAMTS5-affected matrix proteins was enriched in basement-membrane components including laminins (LAMA/LAMB/LAMC), collagen-6 (COL6A1/A2), collagen-12 (COL12A1), AGRN, nidogen-1 (NID1), and TINAG (tubulointerstitial nephritis Ag) (Fig. 4F). Here, GRAMD1C is linked to interstitial nephritis.