ADAM17 and Hyperammonemia: Hyperammonemia reduces the phosphorylation at Tyr204 of Erk to 65 ± 9% (Fig. 3e), increases the phosphorylation at Thr180/Tyr182 of p38 to 142 ± 9% (Fig. 3f), and the phosphorylation at Thr735 of ADAM17 to 137 ± 11% (Fig. 3g), of control rats, and these effects are not reversed by strychnine.