In pre-treatment obese T2DM patients, plasma vaspin displayed four statistically significant correlations: positive with HOMA-IR (r = 0.437, p = 0.020), insulin concentration (r = 0.491, p = 0.007), and HOMA-B (r = 0.352, p = 0.006), and a negative with HOMA-S (r = −0.445, p = 0.017). The gene discussed is INS; the disease is type 2 diabetes mellitus.