Among the recently identified regulatory peptides secreted by both adipose tissue and peripheral organs (mainly liver and skeletal muscle), which play an important role in the pathogenesis of metabolic changes in the course of obesity associated with type 2 diabetes, adropin, irisin, and vaspin play an important role [4,5,6,7,8]. This evidence concerns the gene ENHO and obesity due to melanocortin 4 receptor deficiency.