As part of this task, the impact of several factors for which previous analyzes confirmed statistical significance as parameters significantly changing after the implementation of therapeutic treatment in obese T2DM patients, was assessed, including the level of irisin and vaspin, HbA1c, HDL, LDL, TG, ACR, eGFR, glucose, insulin, QUICKI, HOMA-IR, HOMA-S, HOMA-B, and eGDR. This evidence concerns the gene INS and type 2 diabetes mellitus.