TYR and melanoma: The mRNA vaccine tested in the Lipo-MERIT study aims to directly target DC for melanoma therapy [71], and is comprised of several mRNAs that encode four different TAA (MAGE-A3, NY-ESO-1, TPTE, and tyrosinase,) to be presented via MHCI and MHCII, and induce IFN type I driven immune responses due to intrinsic stimulatory activity.