Most recently, Masjedi et al. reported that ex vivo silencing of the adenosine A2A receptor (A2AR) with an A2AR-specific siRNA complexed with PEG-chitosan-lactate (PCL) NPs inhibited the differentiation of CD4+CD25− T cells derived from 4T1 breast tumor-bearing Balb/C mice toward Treg [231]. Here, ADORA2A is linked to breast neoplasm.