CNP and colorectal carcinoma: For lung-specific markers, the CNP, TSGT101, and EPS15 content was 14.5-fold (p-value = 5.7 × 10−5), 6.6-fold (p-value = 7.7 × 10−4), and 5.9-fold (p-value = 3.3 × 10−4) higher in the LC-derived EVs compared to the CRC-derived EVs.