HMOX1 and Alzheimer disease: With special regard to quercetin (a flavonol found related to better cognitive health in our study), it has demonstrated effectiveness in animal models of Alzheimer’s disease in decreasing of oxidative stress [46] and positively modulating Nrf2/HO-1 (nuclear factor erythroid 2–related factor 2/heme oxygenase-1) pathway [47]; also, an effect toward neuro-inflammation through regulation of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) and has been observed [48].