MSX2 and Craniofrontonasal dysplasia: In humans, heterozygous mutations in EFNA4, loss-of-function of EFNB1 in craniofrontonasal syndrome, and the amino acid substitution P148H in MSX2 of Boston-type craniosynostosis syndrome all result in coronal suture fusion in humans [10,136,137,139,140], which further indicates the necessity of coronal suture boundary maintenance for healthy skull development.