However, in breast cancer, while membrane-bound SDC1 promotes cell proliferation and inhibits invasion through FGF2 mediated MAPK signaling, soluble SDC1 deriving from proteolytic cleavage of membrane-bound SDC1 may trigger a switch from a proliferative to an invasive phenotype through Rho GTPase pathways [159]. Here, SDC1 is linked to breast carcinoma.