The HS chains of perlecan are known to bind FGF2 promoting receptor activation, and mitogenic and pro-angiogenic signaling in different tumors, whereas the protein core of perlecan is implicated in FGF7 binding and activation of its receptor and downstream MAPK signaling leading to human colon carcinoma cell growth [38,146,181]. The gene discussed is HSPG2; the disease is colon carcinoma.