Increased expression levels of perlecan have been found in hepatocellular carcinoma, melanoma, pancreatic and prostate cancer, whereas the upregulation of the expression of agrin has been demonstrated in oral squamous cell carcinoma, hepatocellular carcinoma, cholangiocarcinoma, lung carcinoma, oral squamous cell carcinoma, and rectal cancer [35,38,144,145,146,148,149,150,151,152]. The gene discussed is AGRN; the disease is oral cavity squamous cell carcinoma.