The human sulfatase 2 (SULF2) inhibitor 2,4-disulfophenyl-N-tert-butylnitrone (OKN-007) exhibits antitumoral activity in hepatocellular carcinoma and glioblastoma by affecting TGFbeta1/SMAD signaling, and cell proliferation and angiogenesis, respectively [268,269]. This evidence concerns the gene TGFB1 and glioblastoma.