While CPG3 results in being overexpressed in liver cancer, lung squamous cell carcinoma, neuroblastoma, ovarian cancer, testicular germ cell tumor, thyroid cancer, yolk sac tumor and other cancers, reduced levels of GPC3 have been found in breast cancer, colorectal cancer, mesothelioma, non-small-cell lung cancer, neuroblastoma, and renal cell carcinoma [35,105,125,126,127,128,129,130]. This evidence concerns the gene GPC3 and liver cancer.