LAG3 and tuberculosis: We found that both WT and TB splenic CD8 T cells expressed a similar level of checkpoint molecules, lymphocyte-activation gene 3 (LAG-3), programmed cell death 1 (PD-1), and T cell immunoglobulin and mucin domain 3 (TIM-3) (Figure 4A), thus, we compared the CD8 TILs to TB splenic control (Figure 4B).