The statistical analysis showed that pooling together the two analysis, the PSA exosome determination got to 96% of sensitivity and 100% specificity in distinguishing PC from BPH patients, while the IC-ELISA alone showed 98.57% of sensitivity and 80.28% of specificity in distinguishing PC patients from BPH patients, and 100% of both sensitivity and specificity in distinguishing PC patients from healthy individuals [36]. This evidence concerns the gene KLK3 and pachyonychia congenita.