As shown in Figure 3A, the hub genes of compounds with OB ≥ 30% and DL ≥ 0.18 against AD are activator protein 1 (AP-1, also known as JUN, degree = 28), RAC-alpha serine/threonine-protein kinase (AKT1, degree = 26), mitogen-activated protein kinase 1 (MAPK1, degree = 26), MAPK3 (degree = 26), transcription factor p65 (RELA, degree = 25), IL-6 (degree = 22), MAPK8 (degree = 21), heat shock protein 90 alpha family class A member 1 (HSP90AA1, degree = 19), epidermal growth factor receptor (EGFR, degree = 18), MAPK14 (degree = 18), and estrogen receptor (ESR1, degree = 18). This evidence concerns the gene ESR1 and Alzheimer disease.