As shown in Figure 3C, the hub genes of compounds with OB < 30% and DL ≥ 0.18 against AD are signal transducer and activator of transcription 3 (STAT3, degree = 39), AKT1 (degree = 30), JUN (degree = 27), MAPK1 (degree = 24), IL-6 (degree = 19), RELA (degree = 19), IL-2 (degree = 18), MAPK14 (degree = 17), vascular endothelial growth factor A (VEGFA, degree = 17), IL-4 (degree = 17), and MAPK8 (degree = 17). This evidence concerns the gene MAPK1 and Alzheimer disease.