A gene expression inflammatory signature could predict MM progression and patient survival and recently it has been identified an 8-genes signature (IL8, IL10, IL17A, CCL3, CCL5, VEGFA, EBI3 and NOS2) which accurately differentiates monoclonal gammopathy of undetermined significance (MGUS), smoldering myeloma (sMM) and MM [45]. This evidence concerns the gene CXCL8 and Miyoshi myopathy.