In agreement with this argumentation line, we showed that the expressions of caspase-3, caspase-8 and c-caspase-8, which are known markers of intrinsic and extrinsic apoptosis pathways [47], were unchanged or relatively decreased due to combinatorial tumor treatment compared to the either therapies alone and to the untreated control tumors. The gene discussed is CASP3; the disease is neoplasm.