We further assessed to which extent the thermo-chemotherapeutic treatment: (a) affects DNA replication and repair (presence of H2AX and phosphorylated H2AX) in target cells, (b) it induces apoptosis in target cells (presence of p53, PARP cleaved PARP, and of caspases), (c) it renders tumor cells surviving therapy prospectively more sensitive to further therapy sessions (presence of p53, NF-κB, HSPs), and (d) how it impacts tumor vascularity (presence of CD31 and αvβ3) and consequently nutrient supply. Here, TP53 is linked to neoplasm.