In particular and in the view of either therapies alone, magnetic hyperthermia treatments caused a significantly increased H2AX protein expression (p < 0.05, day 9 post first tumor therapy) and only a slightly higher (but not significantly different) expression of phospho-H2AX compared to tumors of the animal group treated with 5FU-MNP (absence of hyperthermia). This evidence concerns the gene H2AX and neoplasm.