H2AX and neoplasm: The combinatorial thermo-chemotherapeutic tumor treatment led to a significantly elevated expression of both H2AX (used as indicator of DNA replication stress, p < 0.001 and p < 0.01, day 9 and day 28 post first tumor therapy, respectively) and the phosphorylated form of H2AX (phospho-H2AX, used as indicator of the presence of DNA double strand brakes, p < 0.05, day 9 post first tumor therapy) compared to the either therapies alone.