Although epitrascriptomics knowledge is in its infancy, the scientific community and the pharmaceutical industry are aware of its therapeutic relevance, particularly in developing an inhibitor of METTL3, which has shown reduced splenomegaly and number of circulating monocytes in a mouse model of AML as well as slowed patient-derived xenograft growth. This evidence concerns the gene METTL3 and acute myeloid leukemia.