FTO and obesity due to melanocortin 4 receptor deficiency: Li et al. showed that the fat mass and obesity-associated (FTO) m6A eraser protein results in being commonly highly expressed in AMLs with 11q23/MLL rearrangements, t(15;17)/PML-RARA, FLT3-ITD, and/or NPM1 mutations and that these oncogenic proteins directly induce FTO gene upregulation [45].