For example, a GBM harboring a high level of αKG and FTO and a low level of METTL3 has an αFMscore equal to +1, while another GBM harboring a low level of αKG and FTO and a low level of METTL3 has an αFMscore equal to +3. Here, METTL3 is linked to glioblastoma.