TP53 and cancer: As shown in Figure 2D, the top rankings include proto-oncogenes (EGFR, ERBB2, BRAF, ABL1, KRAS, KIT, PIK3CA, TP53, PTEN, and CREBBP) and tumor-suppressor genes (TP53, PTEN, and CREBBP), both of which play key roles in the development and progression of most cancers.