In a multicenter, randomized, double-blind trial, acarbose significantly lowered HbA1c, FPG, PPG, and insulin levels and was found to be safe and well tolerated in T2DM patients who were inadequately controlled with diet and Met.48 These studies support the use of α-glucosidase inhibitors as a potential therapeutic option in patients with high PPG level or those who are poorly controlled with other hypoglycemic agents. Here, INS is linked to type 2 diabetes mellitus.