These specific mRNAs play an important role in the epithelial-to-mesenchymal transition observed in tumor cells: many of the targets that were repressed in the favorable ccrcc2_3 subtypes are mRNAs that promote tumor invasiveness and metastasis (MMP3, MMP9, AURKB, FBN2, ITGB4, SPDEF, F2, RUNX2, CDCP1, repressed by miRs 204-5p, 30c-5p, 135a-5p and 106a-5p). This evidence concerns the gene SPDEF and neoplasm.