When it comes to functionality, although Apela mRNA is expressed in human stem cells, prostate, and kidney [8, 17], and Apela can promote angiogenesis and induce vasodilatation in mouse aorta through activating signal transduction pathways [17], and use as a pre-warning biomarker and a novel therapeutic target against progression of heart failure [18]. This evidence concerns the gene APELA and heart failure.