Furthermore, many of the inflammatory cytokines implicated in the development of GvHD have also been known to be involved in hepatic steatosis: Evidence suggests that induction of inflammation from adipose tissue of obese subjects contributes to obesity induced nonalcoholic fatty liver disease in which the IL-1 cytokine superfamily play a role [14] and serum IL-6 levels are higher in animal models and patients with fatty liver disease [15, 16]. This evidence concerns the gene IL6 and fatty liver disease.