The association between elevated CK-18 levels and cell death in the liver [8, 9] has made circulating CK-18 (both M30 and M65 antigens) a candidate marker for detecting NASH and fibrosis [10], as a stand-alone test and, more recently, as part of multimarker models. The gene discussed is KRT18; the disease is metabolic dysfunction-associated steatohepatitis.