We found that the serum levels of ficolin-1 were significantly higher in the PBC patients than in the controls (152 [77–268] ng/mL vs 102 [59–152] ng/mL; P = 0.034), although no significant differences were observed regarding MBL serum levels (1624 [673–2931] ng/mL vs 1164 [1008–1667] ng/mL; P = 0.53), ficolin-2 (1402 [914–2182] ng/mL vs 1204 [927–1765] ng/mL; P = 0.47) and ficolin-3 (23.4 [19.0–28.0] μg/mL vs 26.3 [22.6–29.2] μg/mL; P = 0.22). Here, FCN1 is linked to primary biliary cholangitis.