Among the nine selected candidate antigens, total IgG to sm31, sm32, RP26, LAP1, and GST significantly declined after the treatment with PZQ, indicating that they can be promising candidates in the study to further evaluate antigens for monitoring the transmission of schistosomiasis after MDA, facilitating the control and elimination of the disease [36, 37]. This evidence concerns the gene CERKL and schistosomiasis.