We observed significant (P < 0.05) positive relationships between HDL and BC risk at 3 loci (ABCA1, APOE-APOC1-APOC4-APOC2, and CETP; Fig 2), and between LDL and BC risk at 1 locus (HMGCR, S12 Fig). This evidence concerns the gene APOC2 and breast cancer.