Of note, the fact that we did not observe differences in body weight and adiposity—while this was previously demonstrated in male mice (Fonken et al., 2010; Coomans et al., 2013; Fonken et al., 2013; Kooijman et al., 2015; Lucassen et al., 2016)—may be explained by the use of female instead of male APOE*3-Leiden.CETP mice, as we found that females are less susceptible to high-fat diet-induced obesity (unpublished observation). The gene discussed is APOE; the disease is obesity due to melanocortin 4 receptor deficiency.